Modulation of trinucleotide repeat instability by DNA polymerase β polymorphic variant R137Q
نویسندگان
چکیده
منابع مشابه
Modulation of trinucleotide repeat instability by DNA polymerase β polymorphic variant R137Q
Trinucleotide repeat (TNR) instability is associated with human neurodegenerative diseases and cancer. Recent studies have pointed out that DNA base excision repair (BER) mediated by DNA polymerase β (pol β) plays a crucial role in governing somatic TNR instability in a damage-location dependent manner. It has been shown that the activities and function of BER enzymes and cofactors can be modul...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2017
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0177299